Orthobiologics

Product

Products within the comprehensive line of AlloSync bone grafting solutions are derived from human allograft bone and maintain optimal osteoconductive potential. Demineralized bone graft products also have osteoinductive properties. The comprehensive portfolio includes a wide selection of advanced demineralized bone matrix (DBM) graft options:
- AlloSync Pure demineralized bone matrix
- AlloSync Expand demineralized cortical fibers
- AlloSync demineralized cancellous sponges and cortical fibers
- AlloSync putty, gel, and paste 
 

- AlloSync wedges
AlloSync products provide excellent handling characteristics and can be combined with bioactive fluids, such as platelet-rich plasma (PRP) or cPRP from bone marrow aspirate (BMA).

AlloSync™ Bone Grafts

Revision Bone Dowels offer surgeons a quick and effective solution for filling bone tunnels during staged ACL/PCL revision cases. The use of bone dowels provides an immediate structural and biologic architecture for stability and incorporation. Soaking the dowels in PRP or bone marrow concentrate provides an infusion of growth factors and cells to assist with the incorporation of the scaffold.
The Revision Bone Dowels were treated with the Allowash XG®* process to remove blood and bone marrow elements from the scaffold. The dowels are then preshaped with a tapered tip and cannulated for easier implantation. Treatment with Preservon®* technology allows for the Revision Bone Dowels to be stored in a prehydrated state for up to 5 years.
*Allowash XG and Preservon are a registered trademark of LifeNet Health.

Cannulated Revision Bone Dowels

Allograft Bone 

Human

Secondary (C)

The OsteoAuger™ Bone Graft Harvesting System provides surgeons with an efficient way to recover autogenous, morselized bone from various harvest sites including the calcaneus, distal and proximal tibia, iliac crest, and distal radius. These harvesters are sterile, single-use systems that are available in diameters of 6 mm, 8 mm, and 10 mm. The autogenous morselized bone can be packed into fusion or fracture sites to enhance bone healing and remodeling.

OsteoAuger™ Bone Graft Harvesting System

Autograft Bone 

BoneSync™ BioActive is a second-generation synthetic bone void filler that elicits osteoconductivity and osteostimulative potential, allowing for bony ingrowth across a fracture or fusion site.1 Comprised of a sophisticated trio of components that includes bioactive glass, BoneSync BioActive filler provides healing benefits to patients and is available in a variety of sizes in strip and putty forms.
 
Reference
1. Xynos ID, Hukkanen MV, Batten JJ, Buttery LD, Hench LL, Polak JM. Bioglass 45S5 stimulates osteoblast turnover and enhances bone formation In vitro: implications and applications for bone tissue engineering. Calcif Tissue Int. 2000;67(4):321-9. doi:1.1007/s002230001134

BoneSync™ BioActive Synthetic Bone Void Filler

The BoneSync synthetic bone void filler portfolio provides surgeons with synthetic bone repair products that provide excellent handling characteristics, all with an osteoconductive scaffold for a wide array of bone repair procedures.
The BoneSync portfolio includes:
<ul>
 <li>BoneSync calcium phosphate cement</li>
 <li>BoneSync putty</li>
 <li>BoneSync strips</li>
</ul>

BoneSync™ Synthetic Bone Void Fillers

OSferion is an osteoconductive bone graft substitute and bone void filler consisting of 100% High Purity Beta-Tricalcium Phosphate (β-TCP). OSferion's micro and macro porous structure allows it to be resorbed and replaced by bone during the healing process when used in conjunction with rigid fixation devices. These revolutionary osteotomy wedges have an unprecedented compressive force of 15-20 MPa (2900 pounds/square inch), comparable to cortical bone, adding improved stability to the correction site. 
 

OSferion wedges can be used in conjunction with the Arthrex distal femoral and high tibial opening wedge osteotomy plates and screws. The chamfered wedge design of the implants corresponds to the shape of the open wedge correction performed with the Opening Wedge Osteotomy System. After insertion of the osteotomy plate, the appropriate size OSferion wedges are prepared in a sterile fashion using autogenous blood, or osteotomy site bone marrow and placed within the osteotomy site by hand. The OSferion wedges are placed on either side of the secured osteotomy plate within the osteotomy. They can be trimmed to size using a rongeur.

OSferion Osteotomy Wedge

OSferion is an osteoconductive bone graft substitute and bone void filler consisting of 100% Beta-tricalcium phosphate (β-TCP). OSferion has micro and macro porous structure that allows for excellent cell communication to promote vascularization. It allows for simultaneous controlled absorption and promotion of osteogenesis. The OSferion Trapezoids are innovatively shaped and may be used as a bone void filler in bone-patellar tendon-bone harvest sites. The appropriate size OSferion Trapezoid are prepared in a sterile fashion using autogenous blood and placed within the harvest site by hand. They can be trimmed to size using a rongeur.

OSferion Trapezoid

Features and Benefits:
Quickset calcium phosphate cement* is a macroporous, injectable, hardening and resorbable bone filler provided in an easy-to-use, closed mixing system.
Composition:
The mixing system is a dual-chambered syringe containing a powder and mixing liquid.
The powder chamber contains a mixture of calcium phosphates and an organic polysaccharide polymer; the polysaccharide is a highly biocompatible polymer that optimizes the viscosity, cohesiveness, and macroporosity.
The mixing liquid consists of a sodium phosphate solution that facilitates the setting time (crystallization) of the cement.
The end product is a calcium-deficient apatite very similar to the mineral phase of bone.
* Quickset is a trademark of Graftys, S.A.

Quickset™ Calcium Phosphate Cement

Arthrex Calcium Sulfate BioBeads are comprised of pure synthetic calcium sulfate that resorbs and is replaced with bone during the healing process. The Arthrex Calcium Sulfate BioBeads kit can be used to create various bead sizes (3 mm, 4.5 mm, and 6 mm) and a paste option, providing surgeons a versatile, biodegradable, and biocompatible bone void filler indicated for use at infected sites.

Arthrex Calcium Sulfate BioBeads 

Synthetic Bone Void Fillers

The BioSurge™ cell and bone graft processing system combines the matrices of the AlloSync™ bone grafting solutions line with the Angel® system’s proprietary technology to prepare customized platelet-rich plasma concentrate (cPRP) from bone marrow aspirate (BMA). Hydrated AlloSync bone grafts provide the optimal scaffold for cPRP from BMA, which is a rich source of platelets and nucleated and progenitor cells.

BioSurge™ Cell and Bone Graft Processing System

Bone Repair Kits

ArthroCell™ and ArthroCell Plus bone grafts are osteogenic, osteoinductive, and osteoconductive—the three elements that are essential for bone formation. Both deliver a 100% human-derived product that mimics the structure of native bone, provides optimal handling, and resists irrigation. ArthroCell and ArthroCell Plus bone grafts use a novel DMSO-free cryoprotectant for preservation of cells, eliminating the need to rinse or decant during graft preparation. This viable bone matrix supports the bone remodeling process across a wide array of orthopedic and spinal applications.

Bone

Allograft Bone

Autograft Bone

Synthetic Bone Void Fillers

Bone Repair Kits

Viable Allograft Bone